Performance of Myocardial Perfusion Imaging Using Multi-focus Fan Beam Collimator with Resolution Recovery Reconstruction in a Comparison with Conventional SPECT
نویسندگان
چکیده
OBJECTIVES IQ-SPECT is an advanced high-speed SPECT modality for myocardial perfusion imaging (MPI), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. The aim of this study was to compare IQ-SPECT with conventional SPECT in terms of performance, based on standard clinical protocols. In addition, we examined the concordance between conventional and IQ_SPECT in patients with coronary artery disease (CAD). METHODS Fifty-three patients, undergoing rest-gated MPI for the evaluation of known or suspected CAD, were enrolled in this study. In each patient, conventional SPECT ((99m)Tc-tetrofosmin, 9.6 min and (201)Tl, 12.9 min) was performed, immediately followed by IQ-SPECT, using a short acquisition time (4.3 min for (99m)Tc-tetrofosmin and 6.2 min for (201)Tl). A quantitative analysis was performed on an MPI polar map, using a 20-segment model of the left ventricle. An automated analysis by gated SPECT was carried out to determine the left ventricular volume and function including end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction (LVEF). The degree of concordance between conventional SPECT and IQ-SPECT images was evaluated according to linear regression and Bland-Altman analyses. RESULTS The segmental percent uptake exhibited a significant correlation between IQ-SPECT and conventional SPECT (P<0.05). The mean differences in (99m)Tc-tetrofosmin studies were 1.1±6.6% (apex), 2.8±5.7% (anterior wall), 2.9±6.2% (septal wall), 4.9±6.7% (lateral wall), and 1.8±5.6% (inferior wall). Meanwhile, regarding the (201)Tl-SPECT studies, these values were 1.6±6.9%, 2.0±6.6%, 2.1±5.9%, 3.3±7.2%, and 2.4±5.8%, respectively. Although the mean LVEF in IQ-SPECT tended to be higher than that observed in conventional SPECT (conventional SPECT=64.8±11.8% and IQ-SPECT=68.3±12.1% for (99m)Tc-tetrofosmin; conventional SPECT= 56.0±11.7% and IQ-SPECT=61.5±12.2% for (201)Tl), quantitative parameters were not significantly different between IQ-SPECT and conventional SPECT. CONCLUSION According to the (99m)Tc-tetrofosmin and (201)Tl protocols, IQ-SPECT images were comparable to and in agreement with conventional SPECT images. Our results suggest that IQ-SPECT is a useful technology for MPI SPECT, and can lead to an increase in scan efficiency and patient comfort.
منابع مشابه
Performance of myocardial perfusion imaging using multi-focus fan beam collimator with resolution recovery reconstruction in a comparison with conventional SPECT
Objective: IQSPECT is an advanced high-speed SPECT modality for performing myocardial perfusion imaging (MPI), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. The aim of this study was to compare IQSPECT compared with conventional SPECT interms of performance based on standard clinical protocols. In addition, we examined the concordance between convention...
متن کاملDifferential impact of multi-focus fan beam collimation with L-mode and conventional systems on the accuracy of myocardial perfusion imaging: Quantitative evaluation using phantoms
Objective(s): A novel IQ-SPECTTM method has become widely used in clinical studies. The present study compares the quality of myocardial perfusion images (MPI) acquired using the IQ-SPECTTM (IQ-mode),conventional (180° apart: C-mode) and L-mode (90° apart: L-mode) systems. We assessed spatial resolution, image reproducibility and quantifiability using various physical phantoms. Materials and Me...
متن کاملEvaluation of the Reconstruction Parameters of Brain Dopamine Transporter SPECT Images Obtained by a Fan Beam Collimator: A Comparison with Parallel-hole Collimators
Objective(s): The purpose of this study was to examine the optimal reconstruction parameters for brain dopamine transporter SPECT images obtained with a fan beam collimator and compare the results with those obtained by using parallel-hole collimators.Methods: Data acquisition was performed using two SPECT/CT devices, namely a Symbia T6 and an Infinia Hawkeye 4 (device A and B) equipped with fa...
متن کاملCollimator-detector response compensation in molecular SPECT reconstruction using STIR framework
Introduction:It is well-recognized that collimator-detector response (CDR) is the main image blurring factor in SPECT. In this research, we compensated the images for CDR in molecular SPECT by using STIR reconstruction framework. Methods: To assess resolution recovery capability of the STIR, a phantom containing five point sources along with a micro Derenzo p...
متن کاملThe evaluation of slant hole collimator in myocardial perfusion SPECT: a simulation study
Introduction: We have investigated cardiac SPECT with slant hole collimator in which the holes are slanted towards the target organ, to provide greater sensitivity over the parallel hole collimator. In addition, parallel hole collimator was used to obtain a comparison in FWHM, sensitivity, Compton and photoelectric area values in the simulations. Materials and Methods...
متن کامل